It begins at the middle of the trigeminal ganglion as a flattened plexiform band then it passes through the lateral wall of the cavernous sinus . It gives two branches to the pterygopalatine ganglion and then leaves the skull through the foramen rotundum, where it becomes more cylindrical in form, and firmer in texture. It then crosses the pterygopalatine fossa, inclines lateralward on the back of the maxilla, and enters the orbit through the inferior orbital fissure. It then runs forward on the floor of the orbit, at first in the infraorbital groove and then in the infraorbital canal remaining outside the periosteum of the orbit. It then emerges on the face through the infraorbital foramen and terminates by dividing into palpebral, lateral nasal and labial branches. The nerve is accompanied by the infraorbital branch of (the third part of) the maxillary artery and the accompanying vein.
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