Cardellini had her first major success when she landed one of the starring roles in the NBC series Freaks and Geeks, which debuted during the 1999–2000 season. As Lindsay Weir, an honor student in the midst of an identity crisis, Cardellini earned positive response that subsequently catapulted her to fame. Cardellini starred in the live-action adaptation of Scooby-Doo in 2002, in which she played the cartoon character Velma Dinkley. She later reprised the role of Velma in 2004's Scooby-Doo 2: Monsters Unleashed. She joined the cast of the hospital drama ER in 2003 as Samantha Taggart, a free-spirited nurse. Cardellini acted for six seasons on ER, until the series finale, "And in the End. . . ", and with the cast won the TV Land ensemble Icon Award in 2009.
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