In February 2016, Zoe Kazan joined the cast, along with Holly Hunter and Ray Romano in April 2016. Unlike many of the other portrayals in The Big Sick, Romano's and Hunter's roles in the film were not modeled after Emily V. Gordon's actual parents. Instead, Hunter said that she never contacted or spoke with Gordon's mother before playing the part, as she wanted to "feel my own freedom with the character". In May 2016, Aidy Bryant, Bo Burnham, Adeel Akhtar and Kurt Braunohler also joined the cast of the film. David Alan Grier was cast in The Big Sick after he met with Emily V. Gordon when she was a writer for The Carmichael Show. Grier's role was part of a larger subplot that was ultimately cut from the film's release.
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